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Lyciyunin, a new dimer of feruloyltyramine and five bioactive tyramines from the root of Lycium yunnanense Kuang.
- Source :
- Natural Product Research; Feb2021, Vol. 35 Issue 3, p447-454, 8p
- Publication Year :
- 2021
-
Abstract
- Lyciyunin, a new dimer of feruloyltyramine (1), together with five known tyramines (2–6), was isolated from the water-soluble fraction of an EtOH extract of the root of L. yunnanense. Based on HR-TOF-MS, NMR spectral data and quantum chemistry ECD calculations, the structure of this new compound was determined, including its absolute configuration. Compounds (1–6) were tested for their antioxidant activity using in vitro DPPH radical scavenging assay, and 1–6 showed the moderate antioxidant activities with IC<subscript>50</subscript> values of 12.44 ± 0.39, 21.29 ± 0.75, 24.44 ± 1.63, 21.15 ± 0.66, 21.15 ± 0.66 and 45.15 ± 0.56 μM, respectively. Compounds (5–6) showed anti-inflammatory activity in LPS-induced RAW 264.7 macrophages with the IC<subscript>50</subscript> values of 43.95 ± 6.11 and 33.50 ± 2.04 μM, respectively. [ABSTRACT FROM AUTHOR]
- Subjects :
- ANTIOXIDANT testing
QUANTUM chemistry
MACROPHAGES
Subjects
Details
- Language :
- English
- ISSN :
- 14786419
- Volume :
- 35
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Natural Product Research
- Publication Type :
- Academic Journal
- Accession number :
- 148112390
- Full Text :
- https://doi.org/10.1080/14786419.2019.1636375