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Association Between Serological Responses to Two Zoonotic Ruminant Pathogens and Esophageal Squamous Cell Carcinoma.
- Source :
- Vector-Borne & Zoonotic Diseases; Feb2021, Vol. 21 Issue 2, p125-127, 3p
- Publication Year :
- 2021
-
Abstract
- Questionnaire data have linked contact with ruminants to the risk of esophageal squamous cell carcinoma (ESCC) in high-risk Asian populations. To better understand this observed association, we investigated exposure to two major zoonotic ruminant pathogens relative to ESCC risk. Using enzyme-linked immunosorbent assay, immunofluorescence assay, and Brucella microagglutination test assays, we measured immunoglobulin G anti-Coxiella burnetii and anti-Brucella spp. antibodies in patients with ESCC (n = 177) and population-based controls (n = 177) matched by age, gender, and residence area from the Golestan case–control study in Iran. We found a similarly high seroprevalence of C. burnetii in ESCC cases and controls (75% and 80%, respectively), and a similarly low seroprevalence of Brucella spp. (0% and 0.6%, respectively). While documenting a high exposure to one of two zoonotic ruminant infections, this exposure failed to explain the observed association of ruminant contact and ESCC risk in this high-risk population. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15303667
- Volume :
- 21
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Vector-Borne & Zoonotic Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 148338749
- Full Text :
- https://doi.org/10.1089/vbz.2020.2668