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Stroke etiologies in patients with COVID-19: the SVIN COVID-19 multinational registry.
- Source :
- BMC Neurology; 1/29/2021, Vol. 21 Issue 1, p1-11, 11p
- Publication Year :
- 2021
-
Abstract
- <bold>Background and Purpose: </bold>Coronavirus disease 2019 (COVID-19) is associated with a small but clinically significant risk of stroke, the cause of which is frequently cryptogenic. In a large multinational cohort of consecutive COVID-19 patients with stroke, we evaluated clinical predictors of cryptogenic stroke, short-term functional outcomes and in-hospital mortality among patients according to stroke etiology.<bold>Methods: </bold>We explored clinical characteristics and short-term outcomes of consecutively evaluated patients 18 years of age or older with acute ischemic stroke (AIS) and laboratory-confirmed COVID-19 from 31 hospitals in 4 countries (3/1/20-6/16/20).<bold>Results: </bold>Of the 14.483 laboratory-confirmed patients with COVID-19, 156 (1.1%) were diagnosed with AIS. Sixty-one (39.4%) were female, 84 (67.2%) white, and 88 (61.5%) were between 60 and 79 years of age. The most frequently reported etiology of AIS was cryptogenic (55/129, 42.6%), which was associated with significantly higher white blood cell count, c-reactive protein, and D-dimer levels than non-cryptogenic AIS patients (p</=0.05 for all comparisons). In a multivariable backward stepwise regression model estimating the odds of in-hospital mortality, cryptogenic stroke mechanism was associated with a fivefold greater odds in-hospital mortality than strokes due to any other mechanism (adjusted OR 5.16, 95%CI 1.41-18.87, p = 0.01). In that model, older age (aOR 2.05 per decade, 95%CI 1.35-3.11, p < 0.01) and higher baseline NIHSS (aOR 1.12, 95%CI 1.02-1.21, p = 0.01) were also independently predictive of mortality.<bold>Conclusions: </bold>Our findings suggest that cryptogenic stroke among COVID-19 patients carries a significant risk of early mortality. [ABSTRACT FROM AUTHOR]
- Subjects :
- COVID-19
STROKE patients
LEUKOCYTE count
HOSPITAL mortality
Subjects
Details
- Language :
- English
- ISSN :
- 14712377
- Volume :
- 21
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- BMC Neurology
- Publication Type :
- Academic Journal
- Accession number :
- 148404055
- Full Text :
- https://doi.org/10.1186/s12883-021-02075-1