Synthesis and Study the Biological Activity of New Heterocyclic Compounds Derived From Hydrazide Derivatives.

The work involves synthesis of new compounds derived from 2-substituted-3-thio- acetohydrazide-1,2,4-triazin. The subsituted hydrazine thiocarbothioamide [IV] was obtained via reaction of hydrazide compound [III] with ammonium thiocyanate and HCl. The cyclization of compound [IV] in 4% NaOH led to formation 1,2,4-triazoles [V], which were refluxed with chloro-ethylacetate in ethanol and sodium acetate to give compound [VI]. Condensation of ester-compound [VI] with hydrazine (80%) led to formation new hydrazide compounds [VII]. Ring closure reaction of compound [VII] with 4-aminbenzoic acid in POCl₃ give 1,3,4-oxadiazoles [VIII]. Compound [VIII] was reacted with sub. benzaldehyde to form compounds of Schiff bases [IX]_a-d. The synthesized compounds were diagnosed via IR, Mass and ¹HNMR spectral data. Many of synthesized compounds were examined against activity of antibacterial: gram (+) (Bacillus subtitis, staphylococcus aureus) and gram (-): (E.coli bacteria) and candida tropicalis fungial. To ensure the safety of the synthesis compounds the toxicity was examined. [ABSTRACT FROM AUTHOR]