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Comprehensive assessment of multiple tryptophan metabolites as potential biomarkers for immune checkpoint inhibitors in patients with non-small cell lung cancer.
- Source :
- Clinical & Translational Oncology; 2021, Vol. 23 Issue 2, p418-423, 6p
- Publication Year :
- 2021
-
Abstract
- Purpose: Tryptophan metabolites have immunomodulatory functions, suggesting possible roles in cancer immunity. Methods: Plasma tryptophan metabolites were measured using liquid chromatography/mass spectrometry before immune checkpoint inhibitors (ICIs) in patients with non-small cell lung cancer (NSCLC). Results: The 19 patients with NSCLC had significantly lower levels of tryptophan (p = 0.002) and xanthurenic acid (p = 0.032), and a significantly higher level of 3-hydroxyanthranilic acid (3-HAA) (p = 0.028) compared with the 10 healthy volunteers. The patients achieving objective responses had significantly lower levels of 3-HAA than those who did not (p = 0.045). Receiver operating characteristic analyses determined that the cutoff value of 3-HAA for objective response was 35.4 pmol/mL (sensitivity: 87.5% and specificity: 83.3%). The patients with 3-HAA < 35.4 pmol/mL had significantly longer median progression-free survival (7.0 months) than those without (1.6 months, p = 0.022). Conclusions: Tryptophan metabolites may have a potential for predicting the efficacy of ICIs. Registration number: University Hospital Medical Information Network Clinical Trial Registry 000026140. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 1699048X
- Volume :
- 23
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Clinical & Translational Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 148447800
- Full Text :
- https://doi.org/10.1007/s12094-020-02421-8