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Numerical Study on Electrode Design for Rodent Deep Brain Stimulation With Implantations Cranial to Targeted Nuclei.

Authors :
Butenko, Konstantin
Köhling, Rüdiger
van Rienen, Ursula
Source :
Frontiers in Computational Neuroscience; 2/2/2021, Vol. 15, pN.PAG-N.PAG, 4p
Publication Year :
2021

Abstract

The globus pallidus internus and the subthalamic nucleus are common targets for deep brain stimulation to alleviate symptoms of Parkinson's disease and dystonia. In the rodent models, however, their direct targeting is hindered by the relatively large dimensions of applied electrodes. To reduce the neurological damage, the electrodes are usually implanted cranial to the nuclei, thus exposing the non-targeted brain regions to large electric fields and, in turn, possible undesired stimulation effects. In this numerical study, we analyze the spread of the fields for the conventional electrodes and several modifications. As a result, we present a relatively simple electrode design that allows an efficient focalization of the stimulating field in the inferiorly located nuclei. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
16625188
Volume :
15
Database :
Complementary Index
Journal :
Frontiers in Computational Neuroscience
Publication Type :
Academic Journal
Accession number :
148452217
Full Text :
https://doi.org/10.3389/fncom.2021.631188