Prostate cancer grading, time to go back to the future.

Abbreviation ISUP International Society of Urological Pathology In November 2014, the International Society of Urological Pathology (ISUP) convened a consensus meeting in Chicago, Illinois, USA to consider grading criteria for prostatic adenocarcinoma [1]. While cribriform cancer used to be included in either Gleason pattern 3 or 4, depending on the size and shape of the glands, the ISUP 2014 revision considers all cribriform cancer to be Gleason pattern 4, or even 5 if comedonecrosis is present [19]. An explanation for this increasing interest may be that the Gleason inflation that was fueled by the ISUP 2005 consensus recommendations has pushed a considerable number of cancers from Gleason score 6 to 7 [21]. The 2014 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostatic Carcinoma: definition of grading patterns and proposal for a new grading system. [Extracted from the article]