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Parkinson's disease laterality: a 11C-PE2I PET imaging study.
- Source :
- Journal of Neurology; Feb2021, Vol. 268 Issue 2, p582-589, 8p
- Publication Year :
- 2021
-
Abstract
- Asymmetry of striatal dopaminergic deficits and motor symptoms is a typical characteristic of idiopathic Parkinson's disease (PD). This study aims to characterise the trend of asymmetry in moderate-stage PD. We performed a 19-month longitudinal study in 27 patients with PET-CT imaging and appropriate clinical assessments. <superscript>11</superscript>C-PE2I non-displaceable binding potential (BP<subscript>ND</subscript>) was calculated bilaterally for the striatum at baseline and follow-up to estimate the in vivo density of striatal dopamine transporters (DAT). Changes in striatal <superscript>11</superscript>C-PE2I BP<subscript>ND</subscript> over time were more prominent in the ipsilateral as compared to contralateral side. Changes in MDS-UPDRS-III (motor component of the Movement Disorders Society Unified PD Rating Scale) were not different between the clinically most and least affected body sides. Our data support that the asymmetry in striatal dopaminergic degeneration becomes less prominent in moderate-stage PD. In contrast, during the above period, the asymmetry of motor symptoms was maintained between the clinically most and least affected body sides. [ABSTRACT FROM AUTHOR]
- Subjects :
- PARKINSON'S disease
DIAGNOSTIC imaging
LATERAL dominance
SYMPTOMS
MOVEMENT disorders
Subjects
Details
- Language :
- English
- ISSN :
- 03405354
- Volume :
- 268
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Journal of Neurology
- Publication Type :
- Academic Journal
- Accession number :
- 148676130
- Full Text :
- https://doi.org/10.1007/s00415-020-10204-y