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Formulation and Evaluation of Mouth Dissolving Tablets of Naproxen Sodium.
- Source :
- International Journal of Pharmacy & Life Sciences; Dec2020, Vol. 11 Issue 12, p7130-7135, 6p
- Publication Year :
- 2020
-
Abstract
- Naproxen sodium is an analgesic NSAIDs (Non Steroidal Anti-Inflammatory Drugs) used for the treatment of pain, inflammation, fever and stiffness caused by conditions such as osteoarthritis, rheumatoid arthritis, juvenile arthritis, gout, migraine and dysmenorrhea. However the gastric discomfort caused by drug results in poor patient compliance associated with its conventional dosage forms. So the rational of this investigation was to develop mouth dissolving tablets of Naproxen sodium using various polymers which offers quick onset of action of drug and minimizes the problem of gastric discomfort associated with it. Thus improves patient's compliance, generates rapid response, enhances bio-availability and also reduce the dose of drug. Mouth dissolving tablets of naproxen sodium were prepared from wet granulation method. The tablets were evaluated for thickness, friability, hardness, weight variation, wetting time, disintegrating time and in vitro dissolution studies. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09767126
- Volume :
- 11
- Issue :
- 12
- Database :
- Complementary Index
- Journal :
- International Journal of Pharmacy & Life Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 148795500