ACE2 mutation might explain lower COVID-19 burden in malaria endemic areas.

Keywords: Malaria; COVID-19; ACE2 variants; Natural selection EN Malaria COVID-19 ACE2 variants Natural selection 702 705 4 02/25/21 20210301 NES 210301 Auley De, Aparna Tiwari and Manoswini Dash have contributed equally. As per the malaria-hypertension hypothesis, the T-allele of rs2106809 might be positively selected in populations that are chronically exposed to malaria and hence increase the likelihood of Ang II-mediated hypertension via downregulating I ACE2 i [[7]]. [Extracted from the article]