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TFEB Biology and Agonists at a Glance.
- Source :
- Cells (2073-4409); Feb2021, Vol. 10 Issue 2, p333, 1p
- Publication Year :
- 2021
-
Abstract
- Autophagy is a critical regulator of cellular survival, differentiation, development, and homeostasis, dysregulation of which is associated with diverse diseases including cancer and neurodegenerative diseases. Transcription factor EB (TFEB), a master transcriptional regulator of autophagy and lysosome, can enhance autophagic and lysosomal biogenesis and function. TFEB has attracted a lot of attention owing to its ability to induce the intracellular clearance of pathogenic factors in a variety of disease models, suggesting that novel therapeutic strategies could be based on the modulation of TFEB activity. Therefore, TFEB agonists are a promising strategy to ameliorate diseases implicated with autophagy dysfunction. Recently, several TFEB agonists have been identified and preclinical or clinical trials are applied. In this review, we present an overview of the latest research on TFEB biology and TFEB agonists. [ABSTRACT FROM AUTHOR]
- Subjects :
- LYSOSOMES
BIOLOGY
NEURODEGENERATION
AUTOPHAGY
TRANSCRIPTION factors
CLINICAL trials
Subjects
Details
- Language :
- English
- ISSN :
- 20734409
- Volume :
- 10
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Cells (2073-4409)
- Publication Type :
- Academic Journal
- Accession number :
- 149095702
- Full Text :
- https://doi.org/10.3390/cells10020333