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Single-cell-resolved measurement of enzyme activity at the tissue level using drop-on-demand microkits.
- Source :
- Analyst; 3/7/2021, Vol. 146 Issue 5, p1548-1551, 4p
- Publication Year :
- 2021
-
Abstract
- Drop-on-demand microkits with a diameter of ∼20 μm are used to measure the activity of acetylcholinesterase (AChE) in a brain slice with single-cell resolution. The relative standard deviation from 25 cellular regions reached 73.3% exhibiting the difference of enzyme activity in the brain slice. Therefore, this approach utilizing the well-established kits provides an alternative single-cell-resolved strategy for the elucidation of enzymatic heterogeneity at the tissue level. [ABSTRACT FROM AUTHOR]
- Subjects :
- ENZYMES
STANDARD deviations
TISSUES
MEASUREMENT
ACETYLCHOLINESTERASE
Subjects
Details
- Language :
- English
- ISSN :
- 00032654
- Volume :
- 146
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Analyst
- Publication Type :
- Academic Journal
- Accession number :
- 149121018
- Full Text :
- https://doi.org/10.1039/d0an02247k