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Elevated levels of inflammatory plasma biomarkers are associated with risk of HIV infection.
- Source :
- Retrovirology; 3/17/2021, Vol. 18 Issue 1, p1-11, 11p
- Publication Year :
- 2021
-
Abstract
- Background: To determine if individuals, from HIV-1 serodiscordant couple cohorts from Rwanda and Zambia, who become HIV-positive have a distinct inflammatory biomarker profile compared to individuals who remain HIV-negative, we compared levels of biomarkers in plasma of HIV-negative individuals who either seroconverted (pre-infection) and became HIV-positive or remained HIV-negative (uninfected). Results: We observed that individuals in the combined cohort, as well as those in the individual country cohorts, who later became HIV-1 infected had significantly higher baseline levels of multiple inflammatory cytokines/chemokines compared to individuals who remained HIV-negative. Genital inflammation/ulceration or schistosome infections were not associated with this elevated profile. Defined levels of ITAC and IL-7 were significant predictors of later HIV acquisition in ROC predictive analyses, whereas the classical Th1 and Th2 inflammatory cytokines such as IL-12 and interferon-γ or IL-4, IL-5 and Il-13 were not. Conclusions: Overall, the data show a significant association between increased plasma biomarkers linked to inflammation and immune activation and HIV acquisition and suggests that pre-existing conditions that increase systemic biomarkers represent a factor for increased risk of HIV infection. [ABSTRACT FROM AUTHOR]
- Subjects :
- HIV infections
BIOMARKERS
CHEMOKINES
Subjects
Details
- Language :
- English
- ISSN :
- 17424690
- Volume :
- 18
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Retrovirology
- Publication Type :
- Academic Journal
- Accession number :
- 149335343
- Full Text :
- https://doi.org/10.1186/s12977-021-00552-6