Back to Search
Start Over
Cortisol and Cortisone in Early Childhood in Very-Low-Birthweight Infants and Term-Born Infants.
- Source :
- Hormone Research in Paediatrics; 2020, Vol. 93 Issue 7/8, p453-459, 7p
- Publication Year :
- 2020
-
Abstract
- Introduction: Besides programming of the hypothalamic-pituitary-adrenal (HPA) axis, changes in the activity of 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) could contribute to the later metabolic and cardiovascular consequences of preterm birth. Objective: We compared serum cortisol, cortisone, and cortisol/cortisone ratio in early childhood in very-low-birthweight (VLBW) infants and term appropriate for gestational age (AGA) born infants. Methods: We included 41 VLBW infants, participating in the randomized controlled Neonatal Insulin Replacement Therapy in Europe trial, and 64 term AGA-born infants. Cortisol and cortisone were measured in blood samples taken at 6 months and 2 years corrected age (VLBW children) and at 3 months and 1 and 2 years (term children). At 2 years of (corrected) age (HDL) cholesterol, triglycerides, glucose, and insulin were also measured. Results: During the first 2 years of life, cortisol/cortisone ratio is higher in VLBW children compared to term children. In the total group of children, cortisol/cortisone ratio is positively related to triglycerides at 2 years of (corrected) age. In VLBW children, over the first 2 years of life both cortisol and cortisone are higher in the early-insulin group compared to the standard care group. Conclusions: In VLBW infants, lower 11β-HSD2 activity probably contributes to the long-term metabolic and cardiovascular risks. In VLBW infants, early insulin treatment could affect programming of the HPA axis, resulting in higher cortisol and cortisone levels during early childhood. [ABSTRACT FROM AUTHOR]
- Subjects :
- CORTISONE
HYDROCORTISONE
INFANTS
HYPOTHALAMIC-pituitary-adrenal axis
PREMATURE labor
Subjects
Details
- Language :
- English
- ISSN :
- 16632818
- Volume :
- 93
- Issue :
- 7/8
- Database :
- Complementary Index
- Journal :
- Hormone Research in Paediatrics
- Publication Type :
- Academic Journal
- Accession number :
- 149338137
- Full Text :
- https://doi.org/10.1159/000512784