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Genetic studies of atopy and atopic dermatitis.
- Source :
- British Journal of Dermatology; Jan1997, Vol. 136 Issue 1, p1-5, 5p
- Publication Year :
- 1997
-
Abstract
- Atopy and the atopic disorders are likely to result from multifactorial inheritance, with interaction between genetic and environmental factors. It has been proposed that at least two major mechanisms, non-antigen specific (total IgE levels) and antigen specific (specific IgE antibodies and skin tests), regulate the immune response to allergens in humans; firstly, a gene/genes independent of the human leucocyte antigen system which is involved in the regulation of total IgE levels, and secondly, a specific immune response gene/genes associated with major histocompatibility complex class II genes which are involved in antigen-specific mechanisms. Candidate genes have been proposed for both mechanisms and linkage has been found between atopy and at least three different gene loci. This paper reviews the evidence supporting a genetic basis for atopy and atopic dermatitis and outlines recent advances in the molecular genetic mapping of genes associated with these disorders. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00070963
- Volume :
- 136
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- British Journal of Dermatology
- Publication Type :
- Academic Journal
- Accession number :
- 14942049
- Full Text :
- https://doi.org/10.1111/j.1365-2133.1997.tb08737.x