Back to Search
Start Over
Long Non-Coding RNAs in Multidrug Resistance of Glioblastoma.
- Source :
- Genes; Mar2021, Vol. 12 Issue 3, p455-455, 1p
- Publication Year :
- 2021
-
Abstract
- Glioblastoma, also known as glioblastoma multiforme, is the most aggressive brain tumor in adults. Despite the huge advance in developing novel therapeutic strategies for patients with glioblastoma, the appearance of multidrug resistance (MDR) against the common chemotherapeutic agents, including temozolomide, is considered as one of the important causes for the failure of glioblastoma treatment. On the other hand, recent studies have demonstrated the critical roles of long non-coding RNAs (lncRNAs), particularly in the development of MDR in glioblastoma. Therefore, this article aimed to review lncRNA's contribution to the regulation of MDR and elucidate the underlying mechanisms in glioblastoma, which will open up new lines of inquiry in the treatment of glioblastoma. [ABSTRACT FROM AUTHOR]
- Subjects :
- LINCRNA
METHYLGUANINE
MULTIDRUG resistance
GLIOBLASTOMA multiforme
BRAIN tumors
Subjects
Details
- Language :
- English
- ISSN :
- 20734425
- Volume :
- 12
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Genes
- Publication Type :
- Academic Journal
- Accession number :
- 149556892
- Full Text :
- https://doi.org/10.3390/genes12030455