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Pathways and role of MALAT1 in esophageal and gastric cancer.
- Source :
- Oncology Letters; May2021, Vol. 21 Issue 5, pN.PAG-N.PAG, 1p
- Publication Year :
- 2021
-
Abstract
- Esophageal cancer (EC) and gastric cancer (GC) often have an unfavorable prognosis. Therefore, research is being conducted to identify the molecular mechanisms underlying the tumorigenesis and progression of GC and EC, and to indicate novel therapeutic targets and clinically applicable biomarkers. The dysregulations and roles of long non-coding RNAs (lncRNAs) have been widely reported, and current published literature has shown that lncRNAs play important regulatory roles in the carcinogenesis and progression of EC and GC. The lncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) has been investigated in a number of studies with regard to its pathogenic pathways and association with the prognosis of gastric and esophageal malignancies. As literature on the topic of MALAT1 in EC and GC continues to emerge, the present review aims to summarize all current knowledge on the association between MALAT1 expression and esophagogastric malignancies and to describe the pathogenic pathways and possible prognostic role of MALAT1 in esophagogastric cancer. As research studies on MALAT1 pathways in esophagogastric malignancies are ongoing, new possibilities for the diagnosis, prognosis and therapy of GC and EC are likely to be identified. [ABSTRACT FROM AUTHOR]
- Subjects :
- ESOPHAGEAL cancer
STOMACH cancer
LINCRNA
PROGNOSIS
DIAGNOSIS
Subjects
Details
- Language :
- English
- ISSN :
- 17921074
- Volume :
- 21
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Oncology Letters
- Publication Type :
- Academic Journal
- Accession number :
- 149707837