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CLEC10A is a prognostic biomarker and correlated with clinical pathologic features and immune infiltrates in lung adenocarcinoma.
- Source :
- Journal of Cellular & Molecular Medicine; Apr2021, Vol. 25 Issue 7, p3391-3399, 9p
- Publication Year :
- 2021
-
Abstract
- CLEC10A, (C‐type lectin domain family 10, member A), as the member of C‐type lectin receptors (CLRs), plays a vital role in modulating innate immunity and adaptive immunity and has shown great potential as an immunotherapy target for cancers. However, there is no functional research of CLEC10A in prognostic risk, immunotherapy or any other treatment of lung adenocarcinoma (LUAD). We performed bioinformatics analysis on LUAD data downloaded from TCGA (The Cancer Genome Atlas) and GEO (Gene Expression Omnibus), and jointly analysed with online databases such as HPA, LinkedOmics, TIMER, ESTIMATE and TISIDB. We found that lower expression of CLEC10A was accompanied with worse outcomes of LUAD patients. Moreover, CLEC10A expression was significantly correlated with a variety of the tumour‐infiltrating immune cells (TIICs). As a promising prognosis predictor and potential immunotherapy target, the potential influence and mechanisms of CLEC10A in LUAD deserve further exploring. [ABSTRACT FROM AUTHOR]
- Subjects :
- DOWNLOADING
ADENOCARCINOMA
LUNGS
ONLINE databases
BIOMARKERS
Subjects
Details
- Language :
- English
- ISSN :
- 15821838
- Volume :
- 25
- Issue :
- 7
- Database :
- Complementary Index
- Journal :
- Journal of Cellular & Molecular Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 149730884
- Full Text :
- https://doi.org/10.1111/jcmm.16416