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Efficacy and Safety of a Combination of Shenmai Injection plus Chemotherapy for the Treatment of Lung Cancer: A Meta-Analysis.
- Source :
- Evidence-based Complementary & Alternative Medicine (eCAM); 4/14/2021, p1-13, 13p, 1 Diagram, 1 Chart, 11 Graphs
- Publication Year :
- 2021
-
Abstract
- Objective. To perform a systematic evaluation of the efficacy and safety of combined treatment of Shenmai injection and chemotherapy for lung cancer. Methods. A literature search for randomized controlled trials (RCTs) describing the treatment of lung cancer by Shenmai injection and chemotherapy or chemotherapy alone was performed using the PubMed, Cochrane Library, China National Knowledge Infrastructure (CNKI), Value In Paper (VIP), China BioMed, and Wanfang databases. The databases were searched for entries published before September 1, 2019. Results. Thirty-seven RCTs, comprising a total of 2808 cases, were included in the present meta-analysis. Of these, 1428 cases were treated by Shenmai injection plus chemotherapy, and 1380 cases were treated only by chemotherapy. The results of meta-analysis showed that the combined treatment (Shenmai injection plus chemotherapy) increased the short-term efficacy of treatment (relative risk [RR] = 1.183, 95% confidence interval [CI] = 1.043–1.343, P < 0.01) and improved patients' quality of life (RR = 1.514, 95%CI = 1.211–1.891, P < 0.01) compared with chemotherapy alone. With regard to the adverse effects, the combined treatment markedly reduced the incidence of white blood cell (WBC) reduction (RR = 0.846, 95%CI = 0.760–0.941, P < 0.01), platelet reduction (RR = 0.462, 95% CI = 0.330–0.649, P < 0.01), and hemoglobin reduction (RR = 0.462, 95% CI = 0.330–0.649, P < 0.01) and alleviated drug-induced liver injury (RR = 0.677, 95%CI = 0.463–0.990, P < 0.05). However, it did not offer a significant protective effect (RR = 0.725, 95%CI = 0.358–1.468, P < 0.05). The effect of the combined treatment on the occurrence of vomiting was considerable (RR = 0.889, 95%CI = 0.794–0.996, P < 0.05), and the combined treatment markedly increased the immunity of patients with lung cancer. Conclusion. The combined treatment of Shenmai injection plus chemotherapy enhanced the short-term efficacy of chemotherapy, improved the patient quality of life, alleviated the adverse effects of chemotherapeutics, and increased the patient immunity. These results should be confirmed by large-scale, high-quality RCTs. [ABSTRACT FROM AUTHOR]
- Subjects :
- ONLINE information services
RELATIVE medical risk
HERBAL medicine
META-analysis
MEDICAL databases
INFORMATION storage & retrieval systems
CONFIDENCE intervals
CANCER chemotherapy
SYSTEMATIC reviews
LUNG tumors
TREATMENT effectiveness
QUALITY of life
IMMUNITY
COMBINED modality therapy
MEDLINE
DRUG side effects
CHINESE medicine
THERAPEUTICS
Subjects
Details
- Language :
- English
- ISSN :
- 1741427X
- Database :
- Complementary Index
- Journal :
- Evidence-based Complementary & Alternative Medicine (eCAM)
- Publication Type :
- Academic Journal
- Accession number :
- 149803237
- Full Text :
- https://doi.org/10.1155/2021/7929165