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Risk factors for non-cancer death after surgery in patients with stage I non-small-cell lung cancer.

Authors :
Kanzaki, Ryu
Nagoya, Akihiro
Kanou, Takashi
Ose, Naoko
Funaki, Soichiro
Minami, Masato
Okamoto, Yuna
Tabuchi, Hiroto
Hoshino, Tomoko
Tajima, Tetsuya
Fujii, Makoto
Ohno, Yuko
Shintani, Yasushi
Source :
European Journal of Cardio-Thoracic Surgery; Mar2021, Vol. 59 Issue 3, p633-640, 8p
Publication Year :
2021

Abstract

OBJECTIVES With improvements in the outcome of treatment for non-small-cell lung cancer (NSCLC), other diseases may account for a high death rate after surgery in patients with stage I NSCLC. In the present study, we analysed the associations between the clinical factors and non-cancer death after surgery in these patients. METHODS The records of 514 patients with stage I NSCLC who underwent surgery were retrospectively reviewed; a proportional hazards model for the subdistribution of a competing risk was conducted to define the risk factors for non-cancer death. RESULTS The mean patient age was 67 years. A total of 367 patients (71%) underwent bilobectomy or lobectomy while 147 (29%) underwent sublobar resection. The pathological stage was IA in 386 (75%) and IB in 128 (25%) patients. Three patients (0.6%) died within 90 days after surgery, and 108 (21%) experienced postoperative complications. Until the time of writing this report, 83 patients had died during the follow-up. The cause of death was primary lung cancer in 38 (46%) patients and other diseases in 45 (54%) patients, including non-cancer causes in 29 patients, such as pneumonia, cardiac death and cerebral stroke. According to a multivariable competing risk analysis for non-cancer death age (≥70 years), sex (male), body mass index (BMI <18.5), postoperative complications and % forced expiratory volume in 1 s (<80) were identified as risk factors for postoperative non-cancer death. CONCLUSIONS Advanced age (≥70 years), male sex, low BMI (<18.5), postoperative complications and low preoperative % forced expiratory volume in 1 s (<80) were found to be the risk factors for postoperative non-cancer death after surgery in patients with stage I NSCLC. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
10107940
Volume :
59
Issue :
3
Database :
Complementary Index
Journal :
European Journal of Cardio-Thoracic Surgery
Publication Type :
Academic Journal
Accession number :
149892313
Full Text :
https://doi.org/10.1093/ejcts/ezaa333