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Laccase-Catalyzed 1,4-Dioxane-Mediated Synthesis of Belladine N -Oxides with Anti-Influenza A Virus Activity.
- Source :
- International Journal of Molecular Sciences; Feb2021, Vol. 22 Issue 3, p1337-1337, 1p
- Publication Year :
- 2021
-
Abstract
- Belladine N-oxides active against influenza A virus have been synthetized by a novel laccase-catalyzed 1,4-dioxane-mediated oxidation of aromatic and side-chain modified belladine derivatives. Electron paramagnetic resonance (EPR) analysis confirmed the role of 1,4-dioxane as a co-oxidant. The reaction was chemo-selective, showing a high functional-group compatibility. The novel belladine N-oxides were active against influenza A virus, involving the early stage of the virus replication life cycle. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 16616596
- Volume :
- 22
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- International Journal of Molecular Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 149925619
- Full Text :
- https://doi.org/10.3390/ijms22031337