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Validation of a colorimetric method for determination of paracetamol in exhaled breath condensate.

Authors :
Pourkarim, Fariba
Rahimpour, Elaheh
Khoubnasabjafari, Maryam
Jouyban-Gharamaleki, Vahid
Gharakhani, Afshin
Jouyban, Abolghasem
Source :
Chemical Papers; Jun2021, Vol. 75 Issue 6, p2901-2906, 6p
Publication Year :
2021

Abstract

A redox reaction-based colorimetric method was validated for the qualitative assay and quantitative determination of paracetamol in exhaled breath condensate (EBC). Fe (III) and K<subscript>3</subscript>[Fe(CN)<subscript>6</subscript>] were used as colorimetric reagents in which paracetamol reduces Fe (III) to Fe (II) due to its reducing property. The produced Fe (II) is chelated with K<subscript>3</subscript>[Fe(CN)<subscript>6</subscript>] to form prussian blue colored product which can be detected by the naked eye in the range of 0.2–10.0 μg mL<superscript>−1</superscript>. The fully validated method was used for the determination of paracetamol in EBC of paracetamol poisoning individuals. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
03666352
Volume :
75
Issue :
6
Database :
Complementary Index
Journal :
Chemical Papers
Publication Type :
Academic Journal
Accession number :
149989497
Full Text :
https://doi.org/10.1007/s11696-021-01520-2