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A porphysome-based photodynamic O2 economizer for hypoxic tumor treatment by inhibiting mitochondrial respiration.

Authors :
Zheng‡, Rongrong
Chen‡, Xiayun
Zhao, Linping
Yang, Ni
Guan, Runtian
Chen, Ali
Yu, Xiyong
Cheng, Hong
Wang, Chang
Li, Shiying
Source :
Chemical Communications; 4/30/2021, Vol. 57 Issue 34, p4134-4137, 4p
Publication Year :
2021

Abstract

A porphysome-based photodynamic O<subscript>2</subscript> economizer (P-PAT) is prepared for hypoxic tumor therapy. The self-assembled porphyrin bilayers of P-PAT possess high loading capacity to atovaquone (ATO) (nearly 70%), which could restrain mitochondrial respiration to relieve hypoxia and enhance photodynamic therapy. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
13597345
Volume :
57
Issue :
34
Database :
Complementary Index
Journal :
Chemical Communications
Publication Type :
Academic Journal
Accession number :
150036381
Full Text :
https://doi.org/10.1039/d1cc00544h