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Evaluation of Transforming Growth Factor-β1 and Interleukin-35 Serum Levels in Patients with Placenta Accreta.
- Source :
- Laboratory Medicine; May2021, Vol. 52 Issue 3, p245-249, 5p
- Publication Year :
- 2021
-
Abstract
- Objective Placenta accreta is a pregnancy-related disorder with extreme trophoblast invasion and the adherence of the placenta to the uterine wall. This study aimed to investigate the serum level of transforming growth factor-beta 1 (TGF-β1) and interleukin (IL)-35 in patients with placenta accreta. Methods Thirty-one women with placenta accreta and 57 healthy pregnant women were enrolled. The serum levels of TGF-β1 and IL-35 were measured using the enzyme-linked immunosorbent assay method. Results The serum levels of both TGF-β and IL-35 were significantly higher in the placenta accreta group compared with the group of healthy women (1082.48 pg/mL vs 497.33 pg/mL and 4541.14 pg/mL vs 1306.04 pg/mL; P <.001, respectively). Moreover, the level of TGF-β1 positively correlated with the IL-35 level but other factors such as age, gestations, live births, and abortions did not correlate with IL-35 and TGF-β1 levels. Conclusion The serum levels of IL-35 and TGF-β1 may contribute to the pathogenesis of placenta accreta and could be considered as potential targets in clinical and diagnostic approaches. [ABSTRACT FROM AUTHOR]
- Subjects :
- TRANSFORMING growth factors-beta
INTERLEUKINS
REFERENCE values
CASE-control method
MAGNETIC resonance imaging
PLACENTA accreta
T-test (Statistics)
ENZYME-linked immunosorbent assay
RESEARCH funding
COLLECTION & preservation of biological specimens
DATA analysis software
STATISTICAL correlation
FETAL ultrasonic imaging
BLOOD
Subjects
Details
- Language :
- English
- ISSN :
- 00075027
- Volume :
- 52
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Laboratory Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 150148275
- Full Text :
- https://doi.org/10.1093/labmed/lmaa071