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Hsa_circ_0010957 level is increased and sponges microRNA-125b in CD4+ T cells of patients with systemic lupus erythematosus.
- Source :
- Molecular Medicine Reports; Jun2021, Vol. 23 Issue 6, pN.PAG-N.PAG, 1p
- Publication Year :
- 2021
-
Abstract
- Systemic lupus erythematosus (SLE) is a severe autoimmune disorder, the pathogenesis of which remains largely unknown. The present study aimed to investigate the role and mechanism of circular RNAs in the etiopathogenesis of SLE. CD4<superscript>+</superscript> T cells in patients with SLE expressed higher levels of hsa_circ_0010957 compared with healthy individuals and was a good differentiator of the active from inactive SLE disease. It was also determined that hsa_circ_0010957 mediated microRNA (miR)-125b/STAT3 signaling and subsequent secretion of inflammatory cytokines interleukin (IL)-18, IL-6 and IL-17, which are important factors in the process of SLE. Hsa_circ_0010957 abrogated the proinflammatory effect of IL-6 via the blockade of STAT3 signaling. In conclusion, increased hsa_circ_0010957 may be involved in SLE pathogenesis via miR-125b/STAT3 signaling. Hsa_circ_0010957 promises to be a potential biomarker and therapeutic target for SLE. [ABSTRACT FROM AUTHOR]
- Subjects :
- SYSTEMIC lupus erythematosus
T cells
CIRCULAR RNA
Subjects
Details
- Language :
- English
- ISSN :
- 17912997
- Volume :
- 23
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- Molecular Medicine Reports
- Publication Type :
- Academic Journal
- Accession number :
- 150164862
- Full Text :
- https://doi.org/10.3892/mmr.2021.12108