Back to Search
Start Over
Asymmetric copper-catalyzed propargylic amination with amine hydrochloride salts.
- Source :
- Chemical Communications; 5/11/2021, Vol. 57 Issue 38, p4674-4677, 4p
- Publication Year :
- 2021
-
Abstract
- The highly enantioselective copper-catalyzed propargylic amination of propargylic esters with amine hydrochloride salts has been realized for the first time using copper salts with chiral N,N,P-ligands. This method features a broad substrate scope and wide functional group tolerance, generating propargylic amines in good to excellent yields with high enantioselectivities (up to 99% ee). The utility of the approach was demonstrated by late-stage functionalization of marketed pharmaceuticals. [ABSTRACT FROM AUTHOR]
- Subjects :
- AMINATION
COPPER salts
AMINES
SALTS
FUNCTIONAL groups
Subjects
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 57
- Issue :
- 38
- Database :
- Complementary Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 150249878
- Full Text :
- https://doi.org/10.1039/d1cc00663k