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Primary cerebellar glioblastomas in children: clinical presentation and management.
- Source :
- Neurosurgical Review; Jun2021, Vol. 44 Issue 3, p1747-1754, 8p
- Publication Year :
- 2021
-
Abstract
- Pediatric cerebellar glioblastomas (pcGBMs) are rare and their characteristics remain ill-defined. We conducted a retrospective analysis of pediatric cerebellar glioblastomas who underwent surgery from 2008 to 2019 in our department. Besides, we performed a literature review of the literature data on pcGBMs. Ten children with mean age of 9.4 years were included. During the follow-up, six patients died with mean survival time of 11.7 months, four patients survived with mean follow-up of 28 months. Seven patients underwent molecular analysis, no patients detected IDH1 mutations, four patients (57.1%) had H3K27M mutations, and two patients (28.6%) had MGMT promoter methylation. The literature review identified 38 pcGBMs cases (including ours), with mean age of 8.84 ± 4.20 years (range, 1–16 years). Increased ICP was the commonest sign. Eighteen (47.4%) patients underwent GTR and fifteen (45.5%) patients received STR. Postoperative radiation (RT) was conducted in 28 patients (75.7%) and 23 patients (65.7%) received chemotherapy. During the follow-up, 25 patients died with mean survival time of 12.21 months and 11 patients survived with average follow-up of 29.3 months. Kaplan-Meier survival depicted chemotherapy (P < 0.001) or radiation (P < 0.001) had positive impact on overall survival. Multivariate analysis revealed chemotherapy was a significant predictor of survival with a hazard ratio of 3.264 (P = 0.038). Our study found mean overall survival time for pcGBMs patients was 12.21 months. PcGBMs may have distinct molecular features, with higher incidence of H3K27M mutation and were always IDH1 wild-type. We recommend the routine postoperative radiotherapy and chemotherapy in pcGBMs. [ABSTRACT FROM AUTHOR]
- Subjects :
- SURVIVAL rate
BRAIN tumors
OVERALL survival
ADJUVANT chemotherapy
Subjects
Details
- Language :
- English
- ISSN :
- 03445607
- Volume :
- 44
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Neurosurgical Review
- Publication Type :
- Academic Journal
- Accession number :
- 150301829
- Full Text :
- https://doi.org/10.1007/s10143-020-01373-5