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Primary prophylaxis of bacterial infections and Pneumocystis jirovecii pneumonia in patients with hematologic malignancies and solid tumors: 2020 updated guidelines of the Infectious Diseases Working Party of the German Society of Hematology and Medical Oncology (AGIHO/DGHO).

Authors :
Classen, Annika Y.
Henze, Larissa
von Lilienfeld-Toal, Marie
Maschmeyer, Georg
Sandherr, Michael
Graeff, Luisa Durán
Alakel, Nael
Christopeit, Maximilian
Krause, Stefan W.
Mayer, Karin
Neumann, Silke
Cornely, Oliver A.
Penack, Olaf
Weißinger, Florian
Wolf, Hans-Heinrich
Vehreschild, Jörg Janne
Source :
Annals of Hematology; Jun2021, Vol. 100 Issue 6, p1603-1620, 18p
Publication Year :
2021

Abstract

Hematologic and oncologic patients with chemo- or immunotherapy-related immunosuppression are at substantial risk for bacterial infections and Pneumocystis jirovecii pneumonia (PcP). As bacterial resistances are increasing worldwide and new research reshapes our understanding of the interactions between the human host and bacterial commensals, administration of antibacterial prophylaxis has become a matter of discussion. This guideline constitutes an update of the 2013 published guideline of the Infectious Diseases Working Party (AGIHO) of the German Society for Hematology and Medical Oncology (DGHO). It gives an overview about current strategies for antibacterial prophylaxis in cancer patients while taking into account the impact of antibacterial prophylaxis on the human microbiome and resistance development. Current literature published from January 2012 to August 2020 was searched and evidence-based recommendations were developed by an expert panel. All recommendations were discussed and approved in a consensus conference of the AGIHO prior to publication. As a result, we present a comprehensive update and extension of our guideline for antibacterial and PcP prophylaxis in cancer patients. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
09395555
Volume :
100
Issue :
6
Database :
Complementary Index
Journal :
Annals of Hematology
Publication Type :
Academic Journal
Accession number :
150302144
Full Text :
https://doi.org/10.1007/s00277-021-04452-9