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Burden of critically ill patients with influenza in a French catchment population.

Authors :
Hernu, Romain
Simon, Marie
Baudry, Thomas
Casalegno, Jean-Sébastien
Lina, Bruno
Cour, Martin
Argaud, Laurent
the "Flu in Lyon ICUs" Study Group
Aubrun, Frederic
Guérin, Claude
Allaouchiche, Bernard
Robert, Dominique
Bohé, Julien
Puidupin, Marc
Manchon, Jacques
Liron, Lionel
Source :
Scientific Reports; 5/18/2021, Vol. 11 Issue 1, p1-7, 7p
Publication Year :
2021

Abstract

Despite the particular focus given to influenza since the 2009 influenza A(H1N1) pandemic, true burden of influenza-associated critical illness remains poorly known. The aim of this study was to identify factors influencing influenza burden imposed on intensive care units (ICUs) in a catchment population during recent influenza seasons. From 2008 to 2013, all adult patients admitted with a laboratory-confirmed influenza infection to one of the ICUs in the catchment area were prospectively included. A total of 201 patients (mean age: 63 ± 16, sex-ratio: 1.1) were included. The influenza-related ICU-bed occupancy rate averaged 4.3% over the five influenza seasons, with the highest mean occupancy rate (16.9%) observed during the 2012 winter. In-hospital mortality for the whole cohort was 26%. Influenza A(H1N1)pdm infections (pdm in the mentioned nomenclature refers to Pandemic Disease Mexico 2009), encountered in 51% of cases, were significantly associated with neither longer length of stay nor higher mortality (ICU and hospital) when compared to infections with other virus subtypes. SOFA score (OR, 1.12; 95% CI, 1.04–1.29) was the only independent factor significantly associated with a prolonged hospitalization. These results highlight both the frequency and the severity of influenza-associated critical illness, leading to a sustained activity in ICUs. Severity of the disease, but not A(H1N1)pdm virus, appears to be a major determinant of ICU burden related to influenza. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
20452322
Volume :
11
Issue :
1
Database :
Complementary Index
Journal :
Scientific Reports
Publication Type :
Academic Journal
Accession number :
150363938
Full Text :
https://doi.org/10.1038/s41598-021-89912-y