Antigen-Antibody Studies in the ABO Blood Group System with Particular Reference to Cross-Reacting Antibodies in Group O Sera.

Summary. A comparison has been made between the reactivity of cross-reacting antibody from group O sera titrated against A cells and the reactivity when titrated against cells of group B. It is considered that the experimental findings require the postulation that cross-reacting antibodies which are produced in response to stimulation by antigen A have a different configuration from those produced in response to antigen B. The results also suggest that elution of antibody from cells at 56° may cause minor changes in spatial configuration which diminish the ability of some antibodies to combine with some subgroups of the A system. [ABSTRACT FROM AUTHOR]