Electro-deposition of Nd3+-doped metal-organic frameworks on titanium dioxide nanotube array coated by hydroxyapatite for anti-microbial and anticorrosive implant.

Metal-organic frameworks are well-aligned nanoporous crystals which can be applied to biomedical field, thanks to the large superficial area, ordered pores array, and biocompatible metallic ion composition. In this work, we fabricated a novel Nd³⁺ ion-doped ZIF-8 since there are some reports showing that Nd³⁺ has anti-carcinogenic properties and can be used for therapeutic application in aberrant angiogenesis recently. Therefore, we attempted to use electrochemical anodic oxidation and electrochemical in situ deposition techniques to produce coating which contains Nd³⁺ on Ti implant. And then we detected the biotoxicity, antibacterial function, and corrosion resistance of this new coating so as to facilitate further research on Nd³⁺ ion implantation in vivo. SEM and TEM were applied to observe the surface morphology. N₂ adsorption–desorption was used to investigate the specific surface area and pore structure. The XRD and XPS were carried out to investigate the compound surface including the chemical composition and element-bonding configurations. The corrosion resistance properties of the samples were tested by electrochemical method. ICP was conducted to investigate the release behavior. [ABSTRACT FROM AUTHOR]