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Tumor-Infiltrating Lymphocytes in the Tumor Microenvironment of Laryngeal Squamous Cell Carcinoma: Systematic Review and Meta-Analysis †.

Authors :
Rodrigo, Juan P.
Sánchez-Canteli, Mario
López, Fernando
Wolf, Gregory T.
Hernández-Prera, Juan C.
Williams, Michelle D.
Willems, Stefan M.
Franchi, Alessandro
Coca-Pelaz, Andrés
Ferlito, Alfio
Plzak, Jan
Oriuchi, Noboru
Source :
Biomedicines; May2021, Vol. 9 Issue 5, p486, 1p
Publication Year :
2021

Abstract

The presence of tumor-infiltrating lymphocytes (TIL) in the tumor microenvironment has been demonstrated to be of prognostic value in various cancers. In this systematic review and meta-analysis, we investigated the prognostic value of TIL in laryngeal squamous cell carcinoma (LSCC). We performed a systematic search in PubMed for publications that investigated the prognostic value of TIL in LSCC. A meta-analysis was performed including all studies assessing the association between TIL counts in hematoxylin-eosin (HE)-stained sections, for CD8+ and/or CD3+/CD4+ TIL and overall survival (OS) or disease-free survival (DFS). The pooled meta-analysis showed a favorable prognostic role for stromal TIL in HE sections for OS (HR 0.57, 95% CI 0.36–0.91, p = 0.02), and for DFS (HR 0.56, 95% CI 0.34–0.94, p = 0.03). High CD8+ TIL were associated with a prolonged OS (HR 0.62, 95% CI 0.4–0.97, p = 0.04) and DFS (HR 0.73, 95% CI 0.34–0.94, p = 0.002). High CD3+/CD4+ TIL demonstrated improved OS (HR 0.32, 95% CI 0.16–0.9, p = 0.03) and DFS (HR 0.23, 95% CI 0.10–0.53, p = 0.0005). This meta-analysis confirmed the favorable prognostic significance of TIL in LSCC. High stromal TIL evaluated in HE sections and intra-tumoral and stromal CD3+, CD4+ and/or CD8+ TIL might predict a better clinical outcome. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
22279059
Volume :
9
Issue :
5
Database :
Complementary Index
Journal :
Biomedicines
Publication Type :
Academic Journal
Accession number :
150477512
Full Text :
https://doi.org/10.3390/biomedicines9050486