Two Transition Metal Complexes: Magnetic Properties and Treatment Effect via Focused High-Intensity Ultrasound on Alzheimer's Disease.

Two novel coordination polymers (where Cu for the complex 1 and the Co for the complex 2) with distinct transition metal ions containing 4-(3,5-dicarboxylphenyl)-2-methylpyridine (H₂L), the pyridyl-dicarboxylic acid ligand, have been produced under the solvothermal reaction conditions, and the two compounds' performances and architectures were also characterized. The chemical formulae determined of two complexes are respectively [Cu(L)(H₂O)]·H₂O (1) and [Co₃(L)₂Cl₂(H₂O)₂]·2H₂O (2). Complex 1 exhibits a 2D network with a (3,6)-connected kgd topology based on the dinuclear [Cu₂O₂] units. In complex 2, the linear trinuclear [Co₃(μ-O_carboxylate)₂(COO)₂Cl₂] units with mixed carboxylate and μ-Cl triple bridges are cross-linked by the L ligands into a 3D framework with a (3,6)-connected rtl topology. The complexes' magnetic performances reflected that between consecutive metal ions, there exists the antiferromagnetic coupling. Their treatment activities on Alzheimer's disease (AD) via focused high-intensity ultrasound were evaluated. Firstly, the Annexin V-fluorescein isothiocyanate/propidium iodide staining was implemented for the assessment of the apoptotic neurons percentage after compounds treatment. Next, the Aβ accumulation in the neurons was also detected via employing the western blotting assay. [ABSTRACT FROM AUTHOR]