Traumatic swelling in Weber-Christain disease, due to multiple protease inhibitor deficiencies.

This article discusses traumatic swelling in Weber-Christain disease, which is due to multiple protease inhibitor deficiencies. For many years the patient had complained of painful lumps on the arms and legs, later spreading to the mammae, gluteal area and back, which disappeared, sometimes discharging fluid, leaving depressed scars. Apart from these nodules the patient was found to develop enormous swellings after relatively minor trauma. Biochemical examination of the clotting, fibrinolysis, kallikrein and complement systems of this particular patient showed, besides a slightly depressed C3 level, multiple plasma protease-inhibitor deficiencies.