Back to Search Start Over

Skin Wound-Healing Potential of Polysaccharides from Medicinal Mushroom Auricularia auricula-judae (Bull.).

Skin Wound-Healing Potential of Polysaccharides from Medicinal Mushroom Auricularia auricula-judae (Bull.).

Authors :
Mapoung, Sariya
Umsumarng, Sonthaya
Semmarath, Warathit
Arjsri, Punnida
Thippraphan, Pilaiporn
Yodkeeree, Supachai
(Dejkriengkraikul), Pornngarm Limtrakul
Source :
Journal of Fungi; Apr2021, Vol. 7 Issue 4, p1-16, 16p
Publication Year :
2021

Abstract

Auricularia auricula-judae, a nutrient-rich mushroom used in traditional medicine, is a macrofungi that exhibits various biological properties. In this study, we have reported on the mechanisms that promote the wound-healing effects of a water-soluble polysaccharide-rich extract obtained from A. auricula-judae (AAP). AAP contained high amounts of polysaccharides (349.83 ± 5.00 mg/g extract) with a molecular weight of 158 kDa. The main sugar composition of AAP includes mannose, galactose, and glucose. AAP displayed antioxidant activity in vitro and was able to abort UVBinduced intracellular ROS production in human fibroblasts in cellulo. AAP significantly promoted both fibroblast and keratinocyte proliferation, migration, and invasion, along with augmentation of the wound-healing process by increasing collagen synthesis and decreasing E-cadherin expression (All p < 0.05). Specifically, the AAP significantly accelerated the wound closure in a mice skin wound-healing model on day 9 (2.5%AAP, p = 0.031 vs. control) and day 12 (1% and 2.5%AAP with p = 0.009 and p < 0.001 vs. control, respectively). Overall, our results indicate that the wound-healing activities of AAP can be applied in an AAP-based product for wound management. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
2309608X
Volume :
7
Issue :
4
Database :
Complementary Index
Journal :
Journal of Fungi
Publication Type :
Academic Journal
Accession number :
150940963
Full Text :
https://doi.org/10.3390/jof7040247