Genomics analysis of leukaemia predisposition in X‐linked agammaglobulinaemia.

BCP-ALL of the XLA patients did not show a distinctive methylation profile. X-linked agammaglobulinemia, Bruton's tyrosine kinase, acute lymphoblastic leukemia, acute megakaryoblastic leukemia, tumor suppressor Keywords: X-linked agammaglobulinemia; Bruton's tyrosine kinase; acute lymphoblastic leukemia; acute megakaryoblastic leukemia; tumor suppressor EN X-linked agammaglobulinemia Bruton's tyrosine kinase acute lymphoblastic leukemia acute megakaryoblastic leukemia tumor suppressor 1277 1281 5 06/18/21 20210615 NES 210615 X-linked agammaglobulinemia (XLA) is an inborn error of immunity caused by pathogenic variants in I Bruton's tyrosine kinase i ( I BTK i ). Future studies in which many patients with XLA with leukemia are enrolled may be able to clarify the more detailed characteristics of leukaemic cells in XLA. [Extracted from the article]