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Cucurbit[8]uril facilitated Michael addition for regioselective cysteine modification.
- Source :
- Chemical Communications; 6/21/2021, Vol. 57 Issue 49, p6086-6089, 4p
- Publication Year :
- 2021
-
Abstract
- Utilizing the interactions between tryptophan, methyl viologen and cucurbit[8]uril, we found that the distance between the targeted peptides/protein and the reactive peptide was shortened, which facilitated the Michael addition reaction between cysteine and dehydroalanine. The highest acceleration was observed on cysteines with suitable pK<subscript>a</subscript> and spatial location to tryptophan, suggesting that our system can be used for regioselective cysteine modification. [ABSTRACT FROM AUTHOR]
- Subjects :
- CUCURBITACEAE
MICHAEL reaction
CYSTEINE
TRYPTOPHAN
PEPTIDES
Subjects
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 57
- Issue :
- 49
- Database :
- Complementary Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 150965151
- Full Text :
- https://doi.org/10.1039/d1cc01404h