Back to Search
Start Over
Absence of CG methylation alters the long noncoding transcriptome landscape in multiple species.
- Source :
- FEBS Letters; Jun2021, Vol. 595 Issue 12, p1734-1747, 14p
- Publication Year :
- 2021
-
Abstract
- The noncoding regions throughout the genome are in large part comprised of transposable elements (TEs), some of which are functionalized with long intergenic noncoding RNAs (lincRNAs). DNA methylation is predominantly associated with TEs, but little is known about its contribution to the transcription of lincRNAs. Here, we examine the lincRNA profiles of DNA methylation‐related mutants of five species, Arabidopsis, rice, tomato, maize, and mouse, to elucidate patterns in lincRNA regulation under altered DNA methylation status. Significant activation of lincRNAs was observed in the absence of CG DNA methylation rather than non‐CG. Our study establishes a working model of the contribution of DNA methylation to regulation of the dynamic activity of lincRNA transcription. [ABSTRACT FROM AUTHOR]
- Subjects :
- LINCRNA
DNA methylation
METHYLATION
DNA fingerprinting
CORN
SPECIES
Subjects
Details
- Language :
- English
- ISSN :
- 00145793
- Volume :
- 595
- Issue :
- 12
- Database :
- Complementary Index
- Journal :
- FEBS Letters
- Publication Type :
- Academic Journal
- Accession number :
- 151130016
- Full Text :
- https://doi.org/10.1002/1873-3468.14100