Enhancing antioxidant, antimicrobial and anti‐NSCLC activities of (‐)‐epigallocatechin gallate encapsulated poly(butyl‐2‐cyanoacrylate) nanowires applications in dietary supplements.

Summary: (‐)‐Epigallocatechin gallate (EGCG) exhibits multiple biological activities, but unfortunately with poor stability. Poly(butyl‐2‐cyanoacrylate) (PBCA) nanoparticles have been widely elaborated for nearly 50 years. However, PBCA‐based nanowires (PNWs) were reported scarcely. Here, EGCG‐encapsulated PNWs (EGCG@PNWs) were successfully constructed. Employing PNWs as a delivery material, 2.0 mg EGCG into oil phase as optimum allocation was encapsulated in PNWs, forming EGCG@PNWs with the particle sizes of about 200 nm in diameter and 4 μm in length, encapsulation efficiency of about 93.96 ± 3.01%, and the zeta potential more than −30 mV. Further, the slower EGCG release from EGCG@PNWs (Oil) in 95% ethanol fatty simulant exhibited higher antioxidant activity than that of 50% ethanol. The antibacterial activities against E. coli and S. aureus and the growth inhibition effects on non‐small‐cell lung cancer (NSCLC) were also enhanced. Results revealed that EGCG@PNWs can be used as dietary supplements to enhance antioxidant, antibacterial and anti‐NSCLC effects. [ABSTRACT FROM AUTHOR]