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Protective Effects of Anwulignan against HCl/Ethanol-Induced Acute Gastric Ulcer in Mice.
- Source :
- Evidence-based Complementary & Alternative Medicine (eCAM); 7/15/2021, p1-14, 14p, 2 Color Photographs, 2 Diagrams, 6 Graphs
- Publication Year :
- 2021
-
Abstract
- Gastric ulcer is one of the most common gastrointestinal diseases. Anwulignan (AN) is a major active component of Schisandra sphenanthera Rehd. This study was designed to evaluate the protective effect of AN against the acute gastric ulcer induced by HCl/ethanol in mice. The mice were given HCl/ethanol by gavage to establish an acute gastric ulcer model. Then, the serum and gastric tissue samples were taken for biochemical analyses. The results showed that the pretreatment with AN could significantly reduce the gastric ulcer index (GUI) and increase the ulcer inhibition rate, indicating that AN can protect against gastric ulcers. AN showed its antioxidant roles by decreasing the content of reactive oxygen species (ROS), malondialdehyde (MDA), and 8-hydroxydeoxyguanosine (8-OHdG) and increasing the activity of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) and anti-inflammatory roles by decreasing the content of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-1β (IL-1β), and myeloperoxidase (MPO) and increasing the content of interleukin-2 (IL-2), interleukin-4 (IL-4), interleukin-10 (IL-10), prostaglandin E2 (PGE2), and nitric oxide (NO) in both serum and gastric tissue. Furthermore, AN also activated the NRF2/ARE signaling pathway and inhibited the MAPK/NF-κB signaling pathway. AN improves the acute gastric ulcer induced by HCl/ethanol in mice, which may be mainly through its antioxidant capacity and anti-inflammatory effect. [ABSTRACT FROM AUTHOR]
- Subjects :
- PEPTIC ulcer prevention
INTERLEUKINS
PROSTAGLANDINS E
KRUSKAL-Wallis Test
LIGNANS
ANTI-inflammatory agents
ANIMAL experimentation
DEOXYRIBONUCLEOSIDES
ONE-way analysis of variance
ANTIOXIDANTS
SUPEROXIDE dismutase
MANN Whitney U Test
MALONDIALDEHYDE
CATALASE
PEROXIDASE
CELLULAR signal transduction
TUMOR necrosis factors
DNA-binding proteins
DESCRIPTIVE statistics
PLANT extracts
REACTIVE oxygen species
NITRIC oxide
TRANSCRIPTION factors
MITOGEN-activated protein kinases
ANTIULCER drugs
GASTRIC mucosa
MICE
GLUTATHIONE peroxidase
PHARMACODYNAMICS
Subjects
Details
- Language :
- English
- ISSN :
- 1741427X
- Database :
- Complementary Index
- Journal :
- Evidence-based Complementary & Alternative Medicine (eCAM)
- Publication Type :
- Academic Journal
- Accession number :
- 151426993
- Full Text :
- https://doi.org/10.1155/2021/9998982