STUDY ON EFFECT OF VITAMIN-C AS ADD ON THERAPY WITH ANTIDIABETIC DRUGS IN TYPE-2 DIABETES MELLITUS PATIENTS ASSOCIATED WITH SOD2 GENE POLYMORPHISM.

Diabetes is a metabolic disorder; affect the metabolism of carbohydrates, proteins and lipids. Superoxide dismutase (SOD) is a major antioxidant scavenging enzyme it helps in removal of superoxide. Polymorphism of SOD2 gene may affect the scavenging effect of SOD enzyme which results in rise of oxidative stress in Type-II DM. The present study has been designed to study the effect of vitamin-C as add on therapy with antidiabetic drugs in type-2 diabetes mellitus patients associated with SOD2 gene polymorphism. A total of 64 type-II diabetes mellitus patients associated with SOD2 gene polymorphism (Ala16Val) were enrolled in present study and divided in to two groups i.e. Group A& B. There are three genotypes in each such as CC, CT& TT. Group-A& B patients were treated with metformin1000mg/day+ teneligliptin-20mg/day and metformin 1000mg/day+ teneligliptin 20mg/day+ vitamin C-1000mg/day respectively for 6 months. Glycemic control and oxidative stress was compared before and after 6 months of treatment in both groups. SPSS software was used to analyze the data. All the genotypes of both the groups had shown significant glycemic control (p<0.05). Significant reduction of TAC and elevation of MDA level was found in CT, TT genotype and CC, CT & TT genotype of group-A patients respectively (p<0.05). CC and CT genotype of group-B patients had shown significant elevation of TAC and reduction of MDA level as compared to baseline values (p<0.05). Good glycemic control and reduction of oxidative stress can be achieved with supplementation of vitamin-C along with antidiabetic drugs. [ABSTRACT FROM AUTHOR]