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ChAdOx1 nCoV-19 protection against SARS-CoV-2 in rhesus macaque and ferret challenge models.

Authors :
Lambe, Teresa
Spencer, Alexandra J.
Thomas, Kelly M.
Gooch, Karen E.
Thomas, Stephen
White, Andrew D.
Humphries, Holly E.
Wright, Daniel
Belij-Rammerstorfer, Sandra
Thakur, Nazia
Conceicao, Carina
Watson, Robert
Alden, Leonie
Allen, Lauren
Aram, Marilyn
Bewley, Kevin R.
Brunt, Emily
Brown, Phillip
Cavell, Breeze E.
Cobb, Rebecca
Source :
Communications Biology; 7/26/2021, Vol. 4 Issue 1, p1-12, 12p
Publication Year :
2021

Abstract

Vaccines against SARS-CoV-2 are urgently required, but early development of vaccines against SARS-CoV-1 resulted in enhanced disease after vaccination. Careful assessment of this phenomena is warranted for vaccine development against SARS CoV-2. Here we report detailed immune profiling after ChAdOx1 nCoV-19 (AZD1222) and subsequent high dose challenge in two animal models of SARS-CoV-2 mediated disease. We demonstrate in rhesus macaques the lung pathology caused by SARS-CoV-2 mediated pneumonia is reduced by prior vaccination with ChAdOx1 nCoV-19 which induced neutralising antibody responses after a single intramuscular administration. In a second animal model, ferrets, ChAdOx1 nCoV-19 reduced both virus shedding and lung pathology. Antibody titre were boosted by a second dose. Data from these challenge models on the absence of enhanced disease and the detailed immune profiling, support the continued clinical evaluation of ChAdOx1 nCoV-19. Lambe, Spencer, Thomas, Gilbert and colleagues report on the detailed immune profile of rhesus macaques and ferrets vaccinated against SARS-CoV-2 under high dose challenge. Their findings indicate that the ChAdOx1 nCoV-19 (AZD1222) the vaccine induces immune responses and reduces disease symptoms in both models, including SARS-CoV-2 mediated pneumonia and virus shedding. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
23993642
Volume :
4
Issue :
1
Database :
Complementary Index
Journal :
Communications Biology
Publication Type :
Academic Journal
Accession number :
151585020
Full Text :
https://doi.org/10.1038/s42003-021-02443-0