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Novel PVA-Based Microspheres Co-Loaded with Photothermal Transforming Agent and Chemotherapeutic for Colorectal Cancer Treatment.
- Source :
- Pharmaceutics; Jul2021, Vol. 13 Issue 7, p984-984, 1p
- Publication Year :
- 2021
-
Abstract
- Background: We previously designed an electrospinning chitosan (CS) nanofiber-based carrier, using polyvinyl alcohol (PVA) as an adjuvant to deliver doxorubicin (DOX) and MoS<subscript>2</subscript> nanosheets for postoperative tumor re-occurrence inhibition. However, owing to that the nanofibrous mat is un-injectable, this composite nanofiber is far from being clinically applicable. Materials and Methods: Via modulating the electrospray parameters, polyvinyl alcohol (PVA) beads string doped with DOX and MoS<subscript>2</subscript> (PVA/MoS<subscript>2</subscript>/DOX microspheres) were prepared, which were further crosslinked with glutaraldehyde to obtain the water-stability. Results: Under the 808-nm laser irradiation, MoS<subscript>2</subscript> nanosheets rendered the prepared PVA/MoS<subscript>2</subscript>/DOX microspheres an excellent light-to-heat conversion performance with η of 23.2%. Besides, the heat generated by near-infrared laser irradiation can improve the effect of chemotherapy by promoting the release rate of DOX. HT29 cell and tumor-bearing nude mice were used to systematically study the combined tumor treatment efficiency of composite nanospheres. Conclusion: PVA/MoS<subscript>2</subscript>/DOX nanospheres have excellent photothermal effect and chemotherapy effect, which can completely suppress the tumor recurrence. Therefore, the PVA/MoS<subscript>2</subscript>/DOX nanospheres are anticipated to find potential applications in the treatment of local colorectal cancer. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 19994923
- Volume :
- 13
- Issue :
- 7
- Database :
- Complementary Index
- Journal :
- Pharmaceutics
- Publication Type :
- Academic Journal
- Accession number :
- 151588531
- Full Text :
- https://doi.org/10.3390/pharmaceutics13070984