Predicting the retinal content in omega‐3 fatty acids for age‐related macular‐degeneration.

Adjusted differences black squares and 95% confidence intervals (CIs) (horizontal lines) of observed and predicted retinal -3 PUFAs contents for age-related macular degeneration in donor eyes and humans patients. Interestingly, cholesteryl esters species with -3 PUFAs contributed positively to the estimation of retinal -3 PUFAs content whereas those with -6 PUFAs lowered the prediction index, which is consistent with the well-established competitive metabolism of -3 and -6 PUFAs. Current treatments for age-related macular degeneration (AMD)-the leading cause of blindness in industrialized countries-are restricted to a single form of the disease and cannot always avoid severe visual loss.1 Among emerging preventive strategies, -3 polyunsaturated fatty acids (PUFAs) are enjoying interest as they promote normal retinal structure and function, reduce incidence, and slow progression of AMD, consistently with their abundance in retinal neurons. [Extracted from the article]