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Serum level of high sensitive C-reactive protein and IL − 6 markers in patients with treatment-resistant schizophrenia in Ethiopia: a comparative study.

Authors :
Challa, Feyissa
Seifu, Daniel
Sileshi, Meron
Getahun, Tigist
Geto, Zeleke
Kassa, Desta
Alemayehu, Melkam
Mesfin, Miraf
Fekadu, Abebaw
Woldeamanuel, Yimtubezinash
Source :
BMC Psychiatry; 8/31/2021, Vol. 21 Issue 1, p1-8, 8p, 5 Charts, 1 Graph
Publication Year :
2021

Abstract

Background: Accumulating evidence indicates that schizophrenia is accompanied by significant activation of the immune system; however, there is limited data from low and middle-income countries (LMIC). Inflammatory markers may be more relevant in LMIC settings where infectious conditions are more prevalent and may thus play some role in the causation and maintenance of schizophrenia. The aim of this study was to assess the level of inflammatory markers high sensitive C-reactive protein (hsCRP) and interleukin-6 (IL-6) in patients with schizophrenia. Materials and methods: The study population consisted of a total of 132 study participants; 82 participants with schizophrenia and 50 controls. hsCRP and IL-6 were measured using Cobas Integra 400 Plus and Cobas e 411 analysers respectively. Results: The levels of hsCRP and IL-6 were significantly increased among participants with schizophrenia compared to controls: hsCRP mean value 2.87 ± 5.6 vs 0.67 ± 0.6 mg/L; IL-6 mean value 6.63 ± 5.6 vs 3.37 ± 4.0 pg/ml. Controlling for potential confounders (age, sex and body mass index), having a diagnosis of schizophrenia remained significantly associated with increased hsCRP and IL-6. Conclusion: The results confirm that inflammatory processes may have a role in the pathophysiology of schizophrenia regardless of setting. Despite failure of some interventions with anti-inflammatory properties, interventions to reduce inflammation are still worth pursuing. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
1471244X
Volume :
21
Issue :
1
Database :
Complementary Index
Journal :
BMC Psychiatry
Publication Type :
Academic Journal
Accession number :
152182746
Full Text :
https://doi.org/10.1186/s12888-021-03443-4