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Longitudinal assessment of anti-SARS-CoV-2 immune responses for six months based on the clinical severity of COVID-19.
- Source :
- Journal of Infectious Diseases; Sep2021, Vol. 224 Issue 5, p754-763, 10p
- Publication Year :
- 2021
-
Abstract
- There is insufficient data on the longevity of immunity acquired following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We aimed to evaluate the duration of SARS-CoV-2-specific humoral and cellular immunity according to the clinical severity of coronavirus disease 2019 (COVID-19). The study population comprised asymptomatic (n=14), symptomatic/non-pneumonic (n=42), and pneumonic (n=41) patients. The anti-SARS-CoV-2 IgG and neutralizing antibody (NAb) titers lasted until six months after diagnosis, with positivity rates of 66.7% and 86.9%, respectively. Older age, prolonged viral shedding and accompanying pneumonia were more frequently found in patients with sustained humoral immunity. SARS-CoV-2 specific T-cell response was strongly observed in pneumonic patients and prominent in individuals with sustained humoral immunity. In conclusion, most (> 85%) patients carries NAb until six months after diagnosis of SARS-CoV-2 infection, providing insights for establishing vaccination strategies against COVID-19. [ABSTRACT FROM AUTHOR]
- Subjects :
- COVID-19
IMMUNE response
CELLULAR immunity
SARS-CoV-2
HUMORAL immunity
Subjects
Details
- Language :
- English
- ISSN :
- 00221899
- Volume :
- 224
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Journal of Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 152206516
- Full Text :
- https://doi.org/10.1093/infdis/jiab124