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Epigenome-Wide Association Study Reveals Methylation Loci Associated With Offspring Gestational Diabetes Mellitus Exposure and Maternal Methylome.
- Source :
- Diabetes Care; Sep2021, Vol. 44 Issue 9, p1992-1999, 8p
- Publication Year :
- 2021
-
Abstract
- <bold>Objective: </bold>Gestational diabetes mellitus (GDM) is associated with an increased risk of obesity and insulin resistance in offspring later in life, which might be explained by epigenetic changes in response to maternal hyperglycemic exposure.<bold>Research Design and Methods: </bold>We explored the association between GDM exposure and maternal blood and newborn cord blood methylation in 536 mother-offspring pairs from the prospective FinnGeDi cohort using Illumina MethylationEPIC 850K BeadChip arrays. We assessed two hypotheses. First, we tested for shared maternal and offspring epigenetic effects resulting from GDM exposure. Second, we tested whether GDM exposure and maternal methylation had an epigenetic effect on the offspring.<bold>Results: </bold>We did not find any epigenetic marks (differentially methylated CpG probes) with shared and consistent effects between mothers and offspring. After including maternal methylation in the model, we identified a single significant (false discovery rate 1.38 × 10-2) CpG at the cg22790973 probe (TFCP2) associated with GDM. We identified seven additional FDR-significant interactions of maternal methylation and GDM status, with the strongest association at the same cg22790973 probe (TFCP2), as well as cg03456133, cg24440941 (H3C6), cg20002843 (LOC127841), cg19107264, and cg11493553 located within the UBE3C gene and cg17065901 in FAM13A, both susceptibility genes for type 2 diabetes and BMI, and cg23355087 within the DLGAP2 gene, known to be involved in insulin resistance during pregnancy.<bold>Conclusions: </bold>Our study reveals the potential complexity of the epigenetic transmission between mothers with GDM and their offspring, likely determined by not only GDM exposure but also other factors indicated by maternal epigenetic status, such as maternal metabolic history. [ABSTRACT FROM AUTHOR]
- Subjects :
- GESTATIONAL diabetes
MATERNAL exposure
INSULIN resistance
METHYLATION
FALSE discovery rate
PROTEINS
RESEARCH
RESEARCH methodology
MEDICAL cooperation
EVALUATION research
TYPE 2 diabetes
DNA methylation
COMPARATIVE studies
DNA-binding proteins
QUESTIONNAIRES
RESEARCH funding
TRANSCRIPTION factors
LONGITUDINAL method
Subjects
Details
- Language :
- English
- ISSN :
- 01495992
- Volume :
- 44
- Issue :
- 9
- Database :
- Complementary Index
- Journal :
- Diabetes Care
- Publication Type :
- Academic Journal
- Accession number :
- 152207633
- Full Text :
- https://doi.org/10.2337/dc20-2960