Visible‐Light‐Driven Redox Neutral Direct C−H Amination of Glycine Derivatives and Peptides with N‐Acyloxyphthalimides.

A room temperature, visible‐light‐promoted and redox neutral direct C−H amination of glycine and peptides has been firstly accomplished by using N‐acyloxyphthalimide or ‐succinimide as nitrogen‐radical precursor. The present strategy provides ways to introduce functionalities such as N‐acyloxyphthalimide or ‐succinimide specifically to terminal glycine segment of peptides. Herein, mild conditions and high functional‐group tolerance allow the preparation of non‐natural α‐amino acids and modification of corresponding peptides in this way. [ABSTRACT FROM AUTHOR]