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Serologic Evidence for Exposure to Simian Virus 40 in North American Zoo Workers.
- Source :
- Journal of Infectious Diseases; 12/15/2004, Vol. 190 Issue 12, p2065-2069, 5p
- Publication Year :
- 2004
-
Abstract
- Some laboratories have detected DNA from the macaque polyomavirus simian virus 40 (SV4O) in human tumors, but possible routes of infection remain unknown. In the present study, an enzyme immunoassay using viruslike particles (VLPs) was used to test 254 zoo workers for antibodies to SV40; 25 zoo workers with direct contact with nonhuman primates and 15 other zoo workers (23% vs. 10%, respectively P = .01) were seropositive for 5V40. Additionally, 5V40 seroreactivity confirmed by competitive-inhibition experiments (i.e., blocked by addition of 5V40 VLPs but not by VLPs for BK virus or JC virus, which are related human polyomaviruses) was increased in zoo workers with direct contact with nonhuman primates (10% vs. 3%, respectively; P = .04). 5V40 seroreactivity therefore may reflect zoonotic exposure. [ABSTRACT FROM AUTHOR]
- Subjects :
- SV40 (Virus)
IMMUNOASSAY
SIMIAN viruses
IMMUNOGLOBULINS
VIRUSES
PRIMATES
Subjects
Details
- Language :
- English
- ISSN :
- 00221899
- Volume :
- 190
- Issue :
- 12
- Database :
- Complementary Index
- Journal :
- Journal of Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 15224382
- Full Text :
- https://doi.org/10.1086/425997