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Serum lactate dehydrogenase is a predictive biomarker in patients with oropharyngeal cancer undergoing radiotherapy: Retrospective study on predictive factors.
- Source :
- Head & Neck; Oct2021, Vol. 43 Issue 10, p3132-3141, 10p
- Publication Year :
- 2021
-
Abstract
- Background: The present study aimed to evaluate the prognostic factors in human papillomavirus (HPV)‐positive and HPV‐negative oropharyngeal cancer (OPC) treated with definitive radiotherapy. Methods: We retrospectively evaluated 101 patients with OPC who underwent definitive radiotherapy between 2008 and 2018. Results: The median follow‐up period of the surviving patients was 68 months (range, 8–164 months). The 5‐year overall survival rate was 69.8%. Univariate analyses revealed that poor survival was associated with male sex, smoking ≥30 pack‐years, Eastern Cooperative Oncology Group performance status ≥1, tumor‐node‐metastasis (TNM) stage III‐IV (8th edition), HPV‐negativity, serum lactate dehydrogenase (LDH) ≥202, C‐reactive protein/albumin ratio ≥0.15, and lymphocyte‐to‐monocyte ratio <2.90. In multivariate analyses, poor survival was independently correlated with smoking ≥30 pack‐years (p < 0.01) and LDH ≥202 (p = 0.02). Conclusions: The present study suggested that high LDH levels predicted poor survival after definitive radiotherapy for patients with both HPV‐positive and HPV‐negative OPC. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10433074
- Volume :
- 43
- Issue :
- 10
- Database :
- Complementary Index
- Journal :
- Head & Neck
- Publication Type :
- Academic Journal
- Accession number :
- 152275983
- Full Text :
- https://doi.org/10.1002/hed.26814